She stated: "PCNA is like a major airline terminal hub containing multiple plane gates. Data suggests PCNA is uniquely altered in cancer cells, and this fact allowed us to design a drug that targeted only the form of PCNA in cancer cells.

"Our cancer-killing capsule is sort of a snowstorm that closes a key airline hub, shutting down all flights out and in solely in planes carrying most cancers cells.

"Results have been promising. AOH1996 can suppress tumor growth as a monotherapy or combination treatment in cell and animal models without resulting in toxicity. The investigational chemotherapeutic is currently in a Phase 1 clinical trial in humans at City of Hope."

As a subsequent step, the researchers will look to raised perceive the mechanism of motion to additional enhance the continued scientific trial in people.

City of Hope's groundbreaking translational analysis historical past contains growing the expertise underlying artificial human insulin, a breakthrough in diabetes administration, and monoclonal antibodies, that are integral to extensively used, lifesaving most cancers medication, similar to trastuzumab, rituximab and cetuximab.