Both gamers missed final weekend’s defeat at Brentford and Grealish has not featured since May 17.
But De Bruyne and Grealish have skilled this weekend and are anticipated to return again into the City group once they face Manchester United at Wembley.
Ruben Dias and Manuel Akanji additionally missed the Brentford recreation however will return and Pep Guardiola has no recent damage considerations.
Back-up goalkeeper Stefan Ortega will begin at Wembley rather than Ederson.
Ortega has began all home cup competitions this season and his inclusion is a giant name after Zack Steffen's high-profile errors in final yr's semi-final defeat by Liverpool.
“He is going to play," said Guardiola. “I have always been like that in the FA Cup. At Barcelona and Bayern as well. The keeper who plays in the FA Cup is going to play.”
When requested in regards to the health of De Bruyne, Grealish and Dias, Guardiola stated: “They trained well last two sessions. They are all of them more or less fine.”
Predicted Manchester City XI (3-2-4-1): Ortega; Walker, Dias, Akanji; Stones, Rodri; Silva, De Bruyne, Gundogan, Grealish; Haaland.
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