Rishi Sunak is going through a by-election triple risk after the Somerton and Frome vote was scheduled for 20 July.
The announcement comes after David Warburton formally left the House of Commons on Monday.
The election will happen on the same day as Boris Johnson's vacated Uxbridge and South Ruislip seat, and Nigel Adams' Selby and Ainsty seat.
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There remains to be no reply on when Nadine Dorries will go away her Mid Bedfordshire constituency, after saying she was "standing down with immediate effect" nearly two weeks ago.
Mr Warburton announced he was standing down as an MP final week, having been suspended from the Conservative Party since April 2022 whereas being investigated by the Independent Complaints and Grievance Scheme (ICGS).
He had been accused of sexual harassment and drug abuse.
In his resignation letter, Mr Warburton mentioned the "malicious allegations" and "flawed" 14-month investigation had "inflicted unimaginable and intolerable destruction on my family and on [himself]".
Mr Warburton's choice to stop means the Conservatives face 4 by-elections at a time when they're trailing behind Labour within the nationwide polls.
All eyes are on Mr Johnson's marginal west London constituency, the place the Conservatives received a 53% share of the vote on the final common election in 2019.
Mr Warburton and Mr Adams are cushioned by bigger majorities of 19,213 and 20,137 respectively, however Labour and the Liberal Democrats are already out campaigning to attempt to swing the constituencies of their favour.
The by-elections come at a tough time for the prime minister, who's struggling to attract a line underneath the Boris Johnson partygate and honours row, whereas additionally going through stress to assist households with soaring mortgage rates.
Mr Warburton has admitted the federal government faces a "tough" contest in his seat, which was held by the Lib Dems earlier than he entered parliament in 2015.
"It's going to be tough for them. I mean, I've won three large majorities in a row, but prior to that it was a Lib Dem seat for 18 years over four elections," he instructed GB News.
"It's going to be difficult and the government is obviously facing three other by-elections ... it's a tough time for by-elections."
Ms Dorries additionally has a big majority of 24,000 however she is holding off the formal strategy of resigning whereas she seeks solutions from Downing Street about why she did not get her peerage.
Mr Johnson had sought to raise the previous tradition secretary to the House of Lords together with Mr Adams however when the listing was lastly revealed, their names were absent - prompting a bitter disagreement between the previous prime minister and Mr Sunak.
Ms Dorries introduced her intention to resign simply earlier than the listing was printed, with Mr Johnson following her hours later over the report from the privileges committee, and Mr Adams stop the subsequent day.
Mr Johnson was discovered to have lied to MPs over the Downing Street events scandal and was stripped of his special access to parliament after the House of Commons voted by 354 to seven to again the inquiry's findings.
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